Oxygenated bioPolymers for biomedical applications

Contact: Gary Chinga Carrasco

An increasing number of patients with chronic wounds have been reported, due to the population´s increasing age and resultant comorbidities like obesity, diabetes and venous insufficiency. The resulting morbidity and cost for the patient and the society is considerable. Healing of chronic wounds is a complicated process, characterized by elevated inflammatory responses, tissue breakdown, and colonization by predominantly anaerobe bacteria, and cause major challenges for the patient´s quality of life. Additionally, the extensive, often inappropriate use of antibiotics, for among others wound treatment, has resulted in an increasing resistance of pathogens against antibiotics. The cost implications for the world community are considerable. Hence, appropriate wound treatment requires optimized dressings that can maintain a prolonged moist environment, with adequate mechanical properties in moist conditions, with targeted antibacterial activity, as well as a barrier against wound bacteria. We propose in the OxyPol project optimized nanocellulose-based dressings as an inexpensive therapy option. In addition, alginates and chitosan can be used as additional biopolymers to add mechanical stability and potentially reinforce the antimicrobial properties of functionalized nanocellulose hydrogels and wound dressings. Hence, the OxyPol project will combine novel optimized nanocellulose from wood, alginates and chitosan, to form tailor-made gels for biomedical applications, focusing on wound dressings. The manufacturing of optimized gels will be upscaled following good manufacturing practices (GMP), and pre-clinical studies will be conducted to confirm the potential of the innovative wound dressing products.

Oxygenated biopolymer gel for wound healing. Photo: GCH. RISE PFI.

Project period: 2020 – 2022

Oxy Solutions is the owner of the OxyPol project. RISE PFI and RISE Bioscience and Materials are the R&D partners.

The project is funded by the Research Council of Norway, through the Nano2021 program.

Project Meetings

200318 Project Meeting – Skype

200213 KickOff – Oxy Solutions, Oslo

Dissemination

Electronic media

200218 – Participation on Aerogels Conference – LinkedIn post

191217 – OxyPol commmunication – LinkedIn post

Conferences

200218 – Chinga-Carrasco, G. “Properties of carboxylated cellulose nanofibrils and application in advanced wound dressings”. International Conference on Aerogels for Biomedical and Environmental Applications, 18-20 February 2020, Santiago de Compostela, Spain